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MilliporeSigma™ Calbiochem™ U-73122

Catalog No. 6620355MG
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Quantity:
5 mg

U-73122, CAS 112648-68-7, inhibits agonist-induced phospholipase C activation (IC50 = 1 to 2.1 μM) in human platelets and neutrophils.

Inhibits agonist-induced phospholipase C activation (IC50 = 1-2.1μM) in human platelets and neutrophils. Inhibits ET-1 and parathyroid hormone-induced Ca2+ transients (IC50 = 800nM and 500 nM, respectively). Also inhibits agonist-induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. Acts as a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces (IC50 = 50 nM). Reported to abolish T lymphoma cell invasion into fibroblast monolayers.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 98% by HPLC
Target Proteins Agonist-induced phospholipase C activation
CAS 112648-68-7
Molecular Formula C29H40N2O3
Formula Weight 464.7g/mol
Solubility CHCl3, DMSO, or EtOH (Reconstitute in DMSO just prior to use)
Form Solid
Quantity 5 mg
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