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MilliporeSigma™ Calbiochem™ U-73122
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Quantity:
5 mg
Description
Inhibits agonist-induced phospholipase C activation (IC50 = 1-2.1μM) in human platelets and neutrophils. Inhibits ET-1 and parathyroid hormone-induced Ca2+ transients (IC50 = 800nM and 500 nM, respectively). Also inhibits agonist-induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. Acts as a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces (IC50 = 50 nM). Reported to abolish T lymphoma cell invasion into fibroblast monolayers.

Specifications
Specifications
Color | Off-white |
Description | 98% by HPLC |
Target Proteins | Agonist-induced phospholipase C activation |
CAS | 112648-68-7 |
Molecular Formula | C29H40N2O3 |
Formula Weight | 464.7g/mol |
Solubility | CHCl3, DMSO, or EtOH (Reconstitute in DMSO just prior to use) |
Form | Solid |
Quantity | 5 mg |
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