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MilliporeSigma™ Calbiochem™ V-ATPase Inhibitor, KM91104

Catalog No. 67299910MG Shop All MilliporeSigma Products
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67-299-910MG 10 mg
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Description

A cell-permeable, non-macrolide small molecule V-ATPase inhibitor that specifically targets the a3-b2 subunit protein protein interation of V-ATPase (IC50 o

A cell-permeable, non-macrolide small molecule V-ATPase inhibitor that specifically targets the a3-b2 subunit protein protein interation of V-ATPase (IC50 of 2.3μM), in vitro . It is also shown to inhibit osteoclast resorption (IC50 of 1.2μM) on both synthetic hydroxyapatite surfaces and dentin slices in an in vitro osteoclast model, RANKL-differentiated RAW 264.7 cells, without significantly affecting RAW 264.7 cell viability or RANKL-mediated osteoclast differentiation.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description >95% by HPLC
Molecular Formula C14H12N2O4
Formula Weight 272.08g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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