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MilliporeSigma™ Calbiochem™ Wnt/β-catenin Inhibitor, Cardamonin

Catalog No. 6816722MG Shop All MilliporeSigma Products
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Description

The Wnt/β-catenin Inhibitor, Cardamonin, also referenced under CAS 19309-14-9, controls the biological activity of Wnt/β-catenin. This small molecule/inhibitor is primarily used for Cancer applications.

Cardamonin, a known 2',4'-dihydroxy-6'-methoxychalcone, was identified as an inhibitor of melanocyte differentiation, among many other pharmacology activities. Cardamonin promoted degradation of intracellular β-catenin while suppressing melanogenesis by down-regulating the expression of MITF and tyrosinase, resulting in decreased melanin content. Furthermore, it was found that cardamonin promoted the degradation of β-catenin through a GSK-3β-independent mechanism, which suggested that Siah-dependent pathway and/or a PKCα-dependent pathway, rather than a GSK-3β-dependent pathway, may mediate intracellularb-catenin degradation by cardamonin.
TRUSTED_SUSTAINABILITY

Specifications

Color Orange-yellow to Amber
Description 95% by HPLC
CAS 19309-14-9
Molecular Formula C16H14O4
Formula Weight 270.28g/mol
Solubility DMSO or EtOH
Form Solid
Quantity 2 mg
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