MilliporeSigma™ Calbiochem™ Wnt/β-catenin Inhibitor, Cardamonin

Description

The Wnt/β-catenin Inhibitor, Cardamonin, also referenced under CAS 19309-14-9, controls the biological activity of Wnt/β-catenin. This small molecule/inhibitor is primarily used for Cancer applications.

Cardamonin, a known 2',4'-dihydroxy-6'-methoxychalcone, was identified as an inhibitor of melanocyte differentiation, among many other pharmacology activities. Cardamonin promoted degradation of intracellular β-catenin while suppressing melanogenesis by down-regulating the expression of MITF and tyrosinase, resulting in decreased melanin content. Furthermore, it was found that cardamonin promoted the degradation of β-catenin through a GSK-3β-independent mechanism, which suggested that Siah-dependent pathway and/or a PKCα-dependent pathway, rather than a GSK-3β-dependent pathway, may mediate intracellularb-catenin degradation by cardamonin.

Specifications

• Color: Orange-yellow to Amber
• Description: 95% by HPLC
• CAS: 19309-14-9
• Molecular Formula: C₁₆H₁₄O₄
• Formula Weight: 270.28g/mol
• Solubility: DMSO or EtOH
• Form: Solid
• Quantity: 2 mg