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Apexbio Technology LLC Calcipotriol 112965-21-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A32715.1
Calcipotriol is a synthetic analogue of vitamin D3 known to bind and activate the vitamin D receptor (VDR) Upon binding to VDR Calcipotriol modulates gene transcription involved in cellular differentiation and proliferation pathways This compound demonstrates regulatory effects on immune cells particularly T cells implicated in psoriasis pathogenesis and induces apoptosis in keratinocytes isolated from psoriasis lesions Calcipotriol also triggers autophagic processes in keratinocytes and HeLa cells in vitro Additionally it suppresses proliferation of various human tumor cell lines including HL-60 and MCF-7 in a concentration-dependent manner In research settings Calcipotriol is used to study differentiation proliferation and inflammatory responses of keratinocytes and immune-related cell types
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