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Apexbio Technology LLC Calcitriol 32222-06-3 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B21415.1
Calcitriol the biologically active metabolite of vitamin D3 functions primarily through interaction with the intracellular vitamin D receptor (VDR) regulating transcription of genes involved in mineral homeostasis and immune responses It modulates cellular differentiation proliferation and adaptive immune functions via nuclear receptor-mediated mechanisms In vitro studies demonstrate that calcitriol dose-dependently inhibits lipopolysaccharide (LPS)-stimulated tumor necrosis factor-alpha (TNF- ) and interleukin-1 (IL-1 ) secretion from human peripheral blood mononuclear cells (PBMCs) Additionally animal models indicate that calcitriol administration decreases cytokine release associated with inflammatory stimuli through intracellular calcium-dependent signaling pathways Calcitriol is widely utilized in biomedical research concerning osteometabolic regulation immune modulation and cytokine signaling networks
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