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Eurofins Discoverx Ready-to-Assay CALCRL Calcitonin Receptor Frozen Cells, 2 Vials of Cells. (HTS172RTA)

Catalog No. 502006002
Encompass

The Ready-to-Assay CALCRL Calcitonin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. parathyroid hormone) based activation of CALCRL GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CALCRL (and modulating protein RAMP1) alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CALCRL, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.

Catalog No. 50-200-6002 Supplier Eurofins Discoverx Supplier No. HTS172RTA
May include imposed supplier surcharges.
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The Ready-to-Assay CALCRL Calcitonin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. parathyroid hormone) based activation of CALCRL GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CALCRL (and modulating protein RAMP1) alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CALCRL, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.

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