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Cayman Chemical CalpaIn InhIbItr I 5mg
Supplier: Cayman Chemical 149215 MG
A synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM) cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM); prevents the degradation of IκBα and IκBβ by the ubiquitin-proteasome complex, which blocks activation of NFκB and the production of TNF and IL-1β
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