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Cayman Chemical CalpaIn InhIbItr II 5mg
Supplier: Cayman Chemical 159945 MG
An inhibitor of c-Kit (IC50 200 nM) an inhibitor of PDGFRa PDGFRB and Lyn B (IC50s 540 800 and 510 nM respectively) inhibits stem cell factor-induced proliferation of Ba/F3 cells expressing wild-type KIT (IC50 150 nM) as well as those expressing the KIT mutants KITV559D and KIT27 (IC50s 3 and 5 nM respectively) an inhibitor of SARS-CoV-2 Mpro (Ki 2.6 UM) inhibits replication of SARS-CoV-2 in infected A549 cells (EC50 3.2 UM) decreases lung and nose viral titers as well as reduces lung inflammation and increases survival in ACE2-humanized mice infected with SARS-CoV-2 at 25 mg/kg
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