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Apexbio Technology LLC Calpeptin 117591-20-5 10mM (in 1mL Ethanol)
Supplier: Apexbio Technology LLC A44115.1
Calpeptin (CAS 117591-20-5) is a potent inhibitor of calpains calcium-dependent intracellular cysteine proteases involved in cellular differentiation proliferation and apoptosis It inhibits human calpain 1 with an IC50 of approximately 5 nM In vitro studies demonstrate that Calpeptin suppresses the production of TGF- 1 IL-6 and angiopoietin-1 as well as collagen synthesis in lung fibroblasts In mouse models of bleomycin-induced pulmonary fibrosis Calpeptin treatment reduces pulmonary tissue fibrosis accompanied by decreased expression of IL-6 TGF- 1 angiopoietin-1 and collagen type Ia1 mRNA Calpeptin serves as a valuable tool in fibrosis-related research
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