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Enzo Life Sciences Calphostin C (100µg). CAS: 121263-19-2
Supplier: Enzo Life Sciences BMLEI1980100
Potent and selective inhibitor of the protein kinase C (PKC). Inhibition is via interaction with the regulatory DAG binding site and phorbol ester binding site. Inhibition of PKC has been found to be light dependent. At higher concentrations inhibits myosin light chain kinase, cAMP-dependent protein kinase, protein kinase G, pp60v-src protein tyrosine kinase and DAG kinase. It also inhibits Phospholipase D1 and D2. Induces apoptotic DNA fragmentation and cell death. Kills breast cancer cells.
Has antiviral potential. Inhibits cardiac L-type Ca2+ channels. Cell permeable. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro.
Alternative name: UCN-1028C. Purity: ≥95% (HPLC). Solubility: Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility. Long Term Storage: -20°C.Product Title
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