AdipoGen Calreticulin h rec His

Supplier:  AdipoGen AG40A0132C010

Protein. Human calreticulin aa18-417 is fused at the C-terminus to a His-tag. Source E. coli. Endotoxin content <1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. Purity >90% SDS-PAGE. Calreticulin is involved in regulation of intracellular Ca2 homoeostasis and ER Ca2 capacity. It constitutes together with calnexin and ERp57 the ‘calreticulin/calnexin cycle’ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.

Catalog No. 50-256-2983