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Apexbio Technology LLC CAMPTOTHECIN 250MG
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Supplier:  Apexbio Technology LLC A2877250

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Camptothecin (CAS 7689-03-4) is a small molecule inhibitor that selectively targets topoisomerase I exhibiting an IC50 value of 679 nM It causes DNA damage evident by phosphorylation of histone H2AX ( H2AX) leading to tumor cell death and cellular senescence via the ATM-Chk2-p53-p21 signaling pathway Additionally camptothecin induces autophagy through activation of the AMPK-TSC2-mTOR pathway Preclinical studies demonstrate its anti-tumor activity against tumor cell lines such as SMMC-7721 MCF-7 HCT-116 and NSCLC xenografts underscoring its utility in cancer biology research

Catalog No. 50-000-60770


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