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Apexbio Technology LLC Canertinib dihydrochloride 289499-45-2 100mg
Supplier: Apexbio Technology LLC A3276100
Canertinib dihydrochloride (CAS 289499-45-2) is a small-molecule inhibitor targeting the pan-ErbB family of receptor tyrosine kinases It is designed to irreversibly inhibit ErbB receptors thereby disrupting Akt and MAPK signaling pathways Canertinib dihydrochloride exerts its biological activity primarily through irreversible binding to ErbB receptor family members In cell-based studies Canertinib dihydrochloride demonstrates apoptotic induction and reduced cell viability with an IC50 value of 3 5 nM Apoptosis induction was observed in BT474 (ErbB2-overexpressing breast cancer) and SK-N-SH (neuroblastoma) cell lines Based on these pharmacological properties Canertinib dihydrochloride holds research potential in oncology specifically for investigating ErbB signaling pathways and evaluating anti-tumor effects in cancer models
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