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Cayman Chemical CAP 2hydrochlorIde 10mg
Supplier: Cayman Chemical 3831510 MG
An ionizable cationic lipid; has been used in the generation of LNPs for the delivery of mRNA or saRNA in vivo; LNPs containing CAP 2 and encapsulating saRNA encoding Dmc1 increase Dmc1 levels in seminiferous tubules for a longer period of time than equivalent LNPs encapsulating Dmc1 mRNA in a Dmc1-/- mouse model of male infertility; LNPs containing CAP 2 and encapsulating saRNA encoding Dmc1 increase the percentage of morphologically mature spermatocytes, thickness of the geminate layer , and diameter of the seminiferous tubes in the same mice; sperm isolated from mice administered these LNPs produced viable embryos with isolated mouse oocytes
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