Captopril

Description

Orally active inhibitor of angiotensin-converting enzyme | CAS: 62571-86-2 | C9H15NO3S | 217.283 g/mol

Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density. Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density. Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity

Solubility
Soluble in water (160 mg/ml) at 25°C, sesame and corn oils (<1mg/mL) at 25°C, methanol (>100 mg/ml), ethanol (>100 mg/ml), isopropanol (>100 mg/ml), chloroform (>100 mg/ml), and dichloromethane (>100 mg/ml).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 62571-86-2
• Molecular Formula: C9H15NO3S
• Molecular Weight (g/mol): 217.283
• MDL Number: MFCD00168073
• InChI Key: FAKRSMQSSFJEIM-RQJHMYQMSA-N
• Synonym: captopril, capoten, l-captopril, captopryl, lopirin, cesplon, captolane, tensoprel, acepress, captoril
• PubChem CID: 44093
• ChEBI: CHEBI:3380
• IUPAC Name: (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
• SMILES: CC(CS)C(=O)N1CCCC1C(=O)O

• Melting Point: 104°C to 108°C
• Color: White
• Quantity: 1 g
• Beilstein: 477887
• Merck Index: 14,1774
• Solubility Information: Soluble in water (160mg/ml) at 25°C,sesame and corn oils (<1mg/ml) at 25°C,methanol (>100mg/ml),ethanol (>100mg/ml),isopropanol (>100mg/ml),chloroform (>100mg/ml),and dichloromethane (>100mg/ml).
• Formula Weight: 217.29
• Physical Form: Powder
• Chemical Name or Material: Captopril

Safety and Handling

Hazard Category	H317-H318-H360D
Hazard Statement	GHS H Statement H361-H317 Suspected of damaging fertility or the unborn child. May cause an allergic skin reaction.
Precautionary Statement	P201-P202-P261-P272-P280g-P281-P302+P352-P305+P351+P338-P308+P313-P310-P333+P313-P363-P501c
EINECSNumber	263-607-1
RTECSNumber	UY0550000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only