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Thermo Scientific™ CaptureSelect™ IgA-XL Affinity Matrix
Description
CaptureSelect IgA-XL Affinity Matrix is intended for the purification of human IgA, with no binding to other immunoglobulins. The IgA-XL affinity matrix provides improved binding capacities (>15 g/L IgA) and elution characteristics (full elution at pH 4) compared to CaptureSelect IgA Affinity Matrix.
Features of this affinity matrix include:
- Purification of all IgA serotypes: IgA1, IgA2, dimeric IgA, and S-IgA (secretory IgA)
- IgA purification from plasma, serum, and recombinant sources
- Efficient purification of IgA with high yields and retained activity
- Excellent scalability
- Non-animal-derived
CaptureSelect IgA-XL Affinity Matrix binds to the Fc part of IgA. The high selectivity and yields obtained using IgA-XL Affinity Matrix enable a robust, fast, and efficient purification process with excellent purity obtained in one step.
Animal origin statement
CaptureSelect products contain affinity ligands based on recombinant single-domain antibody fragments (VHH) created by a proprietary technology. The VHH affinity ligand is a 12–15 kDa fragment comprising the three complementarity-determining regions (CDRs) that form the antigen-binding domain, efficiently produced in the yeast Saccharomyces cerevisiae by a production process free of any animal components (animal origin-free).
Main characteristics
- Matrix: agarose-based, epoxide activated
- Average particle size: 65 ± 10 μm
- Ligand: CaptureSelect IgA-XL affinity ligand
- Ligand coupling method: epoxide
- Binding capacity: > 15 g/L at 5 minutes residence time, tested with plasma-derived polyclonal IgA
- Elution conditions: 20 mM sodium citrate, pH 4
- Flow characteristics: 50–200 cm/h (up to 2 bar)
- Formulation buffer: 20% (v/v) ethanol
Specifications
Specifications
| Flow Rate | 50–200 cm/hr. (up to 2 bar) |
| Formulation | 20% (v/v) ethanol |
| Content And Storage | Store at 2–8°C. Protect from direct sunlight. |
| Particle Size | 65 ±10 μm |
| Form | Resin Slurry |
| Product Line | CaptureSelect |
| Quantity | 5 mL |
| For Use With (Application) | Purification of all IgA subtypes (IgA1, IgA2, dimeric IgA, secretory IgA) |
| Target | IgA-Fc domain |
| Type | Affinity Matrix |
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