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Medchemexpress LLC Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, methanesulfonate | 138489-18-6 | 99.6% | 553.65 | 100 MG
SDP

Catalog No. 5000350034
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Ro 31-8220 mesylate is a potent PKC inhibitor that also significantly inhibits MAPKAP-K1b, MSK1, S6K1, and GSK3β. It shows no effect on MKK3, MKK4, MKK6, and MKK7. This compound can inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, demonstrating pharmacological properties independent of PKC. It also directly suppresses voltage-dependent Na+ channels and exhibits neuroprotective qualities.

  • Potent PKC inhibitor with low nanomolar IC50s for various PKC isoforms
  • Significantly inhibits MAPKAP-K1b, MSK1, S6K1, and GSK3β
  • Can inhibit MKP-1 expression and activate JNK
  • Directly suppresses voltage-dependent Na+ channels
  • Neuroprotective against paraoxon-induced neuronal cell death

Catalog No. 50-003-50034 Supplier Medchemexpress LLC Supplier No. HY13866100MG
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Ro 31-8220 mesylate is a potent PKC inhibitor that also significantly inhibits MAPKAP-K1b, MSK1, S6K1, and GSK3β. It shows no effect on MKK3, MKK4, MKK6, and MKK7. This compound can inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, demonstrating pharmacological properties independent of PKC. It also directly suppresses voltage-dependent Na+ channels and exhibits neuroprotective qualities.

  • Potent PKC inhibitor with low nanomolar IC50s for various PKC isoforms
  • Significantly inhibits MAPKAP-K1b, MSK1, S6K1, and GSK3β
  • Can inhibit MKP-1 expression and activate JNK
  • Directly suppresses voltage-dependent Na+ channels
  • Neuroprotective against paraoxon-induced neuronal cell death

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