Carbenoxolone disodium salt, 97+%, Thermo Scientific Chemicals

Description

Carbenoxolone is anti-inflammatory. It is often used as a gap junction inhibitor in neuroscience research. Carbenoxolone is also an inhibitor of the steroid dehydrogenase enzymes 11 β-hydroxysteroid dehydrogenase (human) and 3α, 20 β-hydroxysteroid dehydrogenase (bacterial). It is used for the treatment of digestive tract ulcers, especially in the stomach. Used in the treatment of peptic, mainly gastric, ulcers. It is often used as a gap junction inhibitor in neuroscience research.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in water to 100 mM.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from heat.

Specifications

Chemical Identifiers

• CAS: 7421-40-1
• Molecular Formula: C34H48Na2O7
• Molecular Weight (g/mol): 614.73
• MDL Number: MFCD00079043
• InChI Key: BQENDLAVTKRQMS-SBBGFIFASA-L
• Synonym: carbenoxolone disodium salt, disodium 3beta-3-3-carboxylatopropanoyl oxy-11-oxoolean-12-en-30-oate, disodium 4as,6as,6br,10s,12as,12br,14br-10-3-carboxylatopropanoyl oxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,7,8,8a,10,11,12,12b,14b-dodecahydro-1h-picene-2-carboxylate
• PubChem CID: 133687779
• IUPAC Name: disodium;(2R,4aR,6aS,6aR,6bS,8aS,10R,12aR,14bS)-10-(3-carboxylatopropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate
• SMILES: [Na+].[Na+].[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](OC(=O)CCC([O-])=O)C(C)(C)[C@]3([H])CC[C@@]12C)C([O-])=O

• Color: White to Cream
• Quantity: 5 g
• Merck Index: 14,1793
• Solubility Information: Soluble in water to 100 mM.
• Formula Weight: 614.7
• Percent Purity: ≥97%
• Physical Form: Solid
• Chemical Name or Material: Carbenoxolone disodium salt

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	231-044-0
RTECSNumber	RK0250000
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only