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Medchemexpress LLC Carboxy pyridostatin trifluoroacetate salt | 2444713-88-4 | 99.5% | 820.73 | 1 ML
Supplier: Medchemexpress LLC HY112680A10MM/1ML
Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand with high molecular specificity to RNA on DNA G4s. It reduces ATF-5 protein, inhibits cell proliferation, and hinders stress granule (SG) formation.
- Reduces the size of adult SVZ-derived neurospheres and the number of cells within them (1-25 μM; 3 days).
- Blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures.
- Hindres stress granule (SG) formation in U2OS cells (10 μM; 24 hours).
- Significantly reduces the number of PCNA-expressing cells in the adult SVZ of mice (10 mg/kg; i.p.; every 12 hours; 3 injections).
- Increases the number of OLIG2-expressing cells in the corpus callosum in mice.
- Affects the differentiation of neural stem and progenitor cells in different brain regions.
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