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Medchemexpress LLC Carboxyamidotriazole orotate | 187739-60-2 | 99.7% | 580.76 | 50 MG
Supplier: Medchemexpress LLC HY1612550MG
Carboxyamidotriazole Orotate is an orally bioavailable signal transduction inhibitor. It acts as a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways, demonstrating anti-tumor, anti-inflammatory, and antiangiogenic effects.
- Inhibits cell proliferation in specific leukemia cell lines.
- Reduces phosphorylation of Bcr-Abl kinase targets.
- Induces a 50% growth reduction in chronic myelogenous leukemia (CML) cell lines.
- Demonstrates dose-dependent inhibition of Bcr-Abl levels.
- Exhibits antitumor activity in CML xenografts, leading to increased survival.
- Has been evaluated in multiple clinical trials for various cancers.
- Intended for research use only.
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