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ABclonal Technology Cardiac Troponin I TNNI3
Supplier: ABclonal Technology A2124620UL
Troponin I (TnI) along with TnT and TnC forms the troponin complex in striated muscle where TnI inhibits actin-myosin interactions mediating muscle relaxation The TnI subfamily includes TnI-skeletal-fast-twitch TnI-skeletal-slow-twitch and TnI-cardiac with this gene encoding the cardiac isoform expressed only in cardiac muscle Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM) TnI is a key diagnostic marker for heart failure ischemic heart disease and acute myocardial injury including in COVID-19 patients where elevated levels indicate increased mortality risk particularly in those with pre-existing cardiovascular conditions
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