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Medchemexpress LLC Carm1 degrader-1 hydrochloride | 3032785-00-2 | 99.4% | 1316.14 | C71H99ClN12O8S | 10 MG
Supplier: Medchemexpress LLC HY156152A10MG
CARM1 degrader-1 hydrochloride is a proteolysis-targeting chimera (PROTAC) that induces VHL- and proteasome-dependent degradation of co-activator associated arginine methyltransferase 1 (CARM1). It has a reported DC50 of 8.1 nM and inhibits methylation of CARM1 substrates, which has been shown to reduce breast cancer cell migration. The compound is provided as a hydrochloride salt and is characterized by a high reported purity for research use.
- Potent PROTAC degrader of CARM1 with a low nanomolar DC50.
- Acts through VHL- and proteasome-dependent degradation pathways.
- Reduces methylation of CARM1 substrates such as PABP1 and BAF155.
- Demonstrated effect on breast cancer cell migration in preclinical assays.
- Provided as a hydrochloride salt with high reported purity.
- Available in small research quantities suitable for in vitro studies.
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