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Apexbio Technology LLC SpCas9 mRNA (ARCA 5mCTP ψUTP) 1mg (1mg/mL)
Supplier: Apexbio Technology LLC R10061.0
SpCas9 mRNA (ARCA 5mCTP UTP) encodes Streptococcus pyogenes Cas9 (SpCas9) protein This product can be used with purified guide RNA (gRNA) sequences in the CRISPR/Cas system for recognizing and cleaving genomic DNA targets CRISPR/Cas a defense system has been adapted from the Type II CRISPR/Cas system of S pyogenes for eukaryotic gene editing It requires two key components the Cas9 endonuclease and a non-coding gRNA Guided by a single gRNA Cas9 introduces DNA double-strand breaks (DSBs) at specific genomic sites Cells activate endogenous DNA repair pathways non-homologous end joining (NHEJ) or homology-directed repair (HDR) to repair the targeted DSB SpCas9 mRNA (ARCA 5mCTP UTP)is designed to mimick mature eukaryotic mRNA It contains a cap 0 structure generated via co-transcriptional capping Incorporation of modified nucleotides 5mCTP UTP poly (A) tail minimizes RNA-induced innate immune activation and enhances mRNA stability and lifespan both in vitro and in vivo
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