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Biocare Medical, LLC Caspase-3 Antibody - Concentrate, 0.5 ml
Supplier: Biocare Medical, LLC CP229B
Apoptosis has gained central importance in the study of many biological processes, including neoplasia, neurodegenerative diseases and development. The proteases that mediate apoptosis are called caspases (cysteinyl-aspartic acid proteases). Cleaved caspase-3 antibody detects endogenous levels of the large fragment of activated caspase-3, a protease that mediates apoptosis. Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 subunits. Cleavage of caspase-3 requires aspartic acid at the P1 position. This antibody does not cross-react with other cleaved caspases.
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