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AdipoGen Caspase-4 11 p20 mAb
Supplier: AdipoGen AG20B0060C100
Monoclonal Antibody. Recognizes endogenous full-length protein and activated p20 fragment of mouse and human caspase-4/11. Isotype Mouse IgG2bkappa. Clone Flamy-1. Applications IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. Inflammatory caspases also known as group I caspases are encoded by three main genes in humans, caspase-1, caspase-4 and caspase-5 and three main genes in mouse, caspase-1, caspase-11 and caspase-12. Caspase-11 is the murine orthologue of human caspase-4 and -5. Murine caspase-11 is a poorly characterized member of the caspase-1 subfamily. Caspase-11-deficient embryonic fibroblasts are resistant to apoptosis induced by ectopic expression of caspase-1, suggesting that caspase-11 is an upstream activator of caspase-1. Unlike caspase-1, the expression of caspase-11 is LPS-inducible and it is reasonable to postulate that other members of the family are regulated at the transcriptional or translational level by extracellular stimuli.
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