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Cayman Chemical Caspase37 CelBased ActIvI 96
SDP

Supplier:  Cayman Chemical 70279096 WELL

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A DOT1L inhibitor (IC50 0.3 nM) selective for DOT1L over a panel of 12 additional protein methyltransferases DNMT1 and a panel of 29 receptors and ion channels reduces H3K79me2 levels in MCF-10A breast cancer cells (IC50 8.8 nM) selectively reduces the viability of isolated human cord blood cells transformed with an MLL-AF9 fusion oncogene over those transformed with a TLS-ERG fusion oncogene at 1 and 5 UM adoptive transfer of isolated human CD3 T cells pre-incubated with SGC0946 (0.5 UM) prevents weight loss increases survival and reduces hepatic and colonic lymphocyte infiltration in a xenogeneic mouse model GVHD

Catalog No. 50-289-5281


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