Castanospermine, 99%

Description

Potent alpha and beta-glucosidase inhibitor | CAS: 79831-76-8 | C8H15NO4 | 189.211 g/mol

Castanospermine, is used as a glycosidase inhibitor and antiinflammatory agent.castanospermine is used to inhibit syncytium formation between HIV-infected and CD4-expressing cells and may also interfere with infectivity. It has also been demonstrated that this agent inhibits inflammation at the level of leukocyte extravasation in rat models of experimental adjuvant-induced arthritis and autoimmune encephalomyelitis. Castanospermine is an inhibitor of Glucosidase I, Maltase-glucoamylase, and MANBA. Potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Castanospermine, is used as a glycosidase inhibitor and antiinflammatory agent.castanospermine is used to inhibit syncytium formation between HIV-infected and CD4-expressing cells and may also interfere with infectivity. It has also been demonstrated that this agent inhibits inflammation at the level of leukocyte extravasation in rat models of experimental adjuvant-induced arthritis and autoimmune encephalomyelitis. Castanospermine is an inhibitor of Glucosidase I, Maltase-glucoamylase, and MANBA. Potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.

Solubility
Soluble in water

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 79831-76-8
• Molecular Formula: C8H15NO4
• Molecular Weight (g/mol): 189.211
• MDL Number: MFCD00017555
• InChI Key: JDVVGAQPNNXQDW-TVNFTVLESA-N
• Synonym: castanospermine, castinospermine, 1,6,7,8-tetrahydroxyoctahydroindolizine, 1s,6s,7r,8r,8ar-1,6,7,8-tetrahydroxyindolizidine, 6-epicastanospermine, unii-q0i3184xm7, 6,7-diepicastanospermine, castanospermine, castanospermum australe, 1s,6s,7r,8ar-tetrahydroxyoctahydroindolizine, 1s,6s,7r,8r,8ar-octahydroindolizine-1,6,7,8-tetrol
• PubChem CID: 54445
• ChEBI: CHEBI:27860
• IUPAC Name: (1S,6S,7R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,6,7,8-tetrol
• SMILES: C1CN2CC(C(C(C2C1O)O)O)O

• Melting Point: 213°C to 217°C
• Color: White
• Quantity: 500 mg
• Beilstein: 3588654
• Merck Index: 14,1896
• Solubility Information: Soluble in water
• Formula Weight: 189.21
• Percent Purity: 99%
• Physical Form: Solid
• Chemical Name or Material: Castanospermine

Safety and Handling

Hazard Category	H302+H312+H332
Hazard Statement	GHS H Statement H302-H312-H332 Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P312-P330-P363-P501c
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only