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Apexbio Technology LLC CB-5083 1542705-92-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B60325.1
CB-5083 (CAS 1542705-92-9) is an orally bioavailable small-molecule inhibitor targeting the AAA ATPase p97 (also termed valosin-containing protein VCP) P97 functions in diverse cellular processes related to protein homeostasis including membrane fusion intracellular trafficking and degradation pathways CB-5083 selectively inhibits the second ATPase domain of p97 (IC50 15 4 nM) promoting cytoplasmic protein degradation and triggering apoptosis in cultured cancer cell lines such as A549 and HCT116 In vivo orally administered CB-5083 demonstrates significant reduction of tumor growth in xenograft models The compound is being investigated clinically for treatment of solid tumors and multiple myeloma
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