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Apexbio Technology LLC CBL0137 (hydrochloride) 1197397-89-9 2mg
Supplier: Apexbio Technology LLC C31922
CBL0137 (hydrochloride) (CAS 1197397-89-9) is a small-molecule curaxin that modulates transcriptional regulation by targeting the Facilitates Chromatin Transcription (FACT) complex This interaction leads to activation of p53 (EC50 0 37 M) and inhibition of NF- B signaling (EC50 0 47 M) pathways commonly dysregulated in cancer In vitro CBL0137 induces apoptosis in pancreatic cancer cell lines affecting both differentiated tumor cells and cancer stem cells In vivo studies demonstrate antitumor activity in models resistant to gemcitabine with additional combinatory effects attributed to transcriptional inhibition CBL0137 is under clinical evaluation in solid and hematological malignancies
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