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Medchemexpress LLC CC-401 hydrochloride | 1438391-30-0 | 99.35% | 100 MG
SDP

Catalog No. 5000340964
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CC-401 hydrochloride is a potent inhibitor of all three forms of JNK, with a Ki ranging from 25 to 50 nM. It demonstrates significant selectivity for JNK over other related kinases and provides specific JNK inhibition in cell-based assays. This compound achieves its effect by competitively binding to the ATP binding site in JNK, thereby inhibiting the phosphorylation of the N-terminal activation domain of c-Jun.

  • Potent inhibitor of all three forms of JNK (Ki: 25-50 nM).
  • Exhibits at least 40-fold selectivity for JNK compared to other related kinases.
  • Provides specific JNK inhibition at concentrations of 1 to 5 μM in cell-based assays.
  • Competitively binds the ATP binding site in JNK.
  • Inhibits phosphorylation of the N-terminal activation domain of c-Jun.
  • Inhibits sorbitol-induced phosphorylation of c-Jun in HK-2 human tubular epithelial cells.
  • Slows progression of proteinuria and prevents renal impairment in animal models.

Catalog No. 50-003-40964 Supplier Medchemexpress LLC Supplier No. HY13022100MG
May include imposed supplier surcharges.
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CC-401 hydrochloride is a potent inhibitor of all three forms of JNK, with a Ki ranging from 25 to 50 nM. It demonstrates significant selectivity for JNK over other related kinases and provides specific JNK inhibition in cell-based assays. This compound achieves its effect by competitively binding to the ATP binding site in JNK, thereby inhibiting the phosphorylation of the N-terminal activation domain of c-Jun.

  • Potent inhibitor of all three forms of JNK (Ki: 25-50 nM).
  • Exhibits at least 40-fold selectivity for JNK compared to other related kinases.
  • Provides specific JNK inhibition at concentrations of 1 to 5 μM in cell-based assays.
  • Competitively binds the ATP binding site in JNK.
  • Inhibits phosphorylation of the N-terminal activation domain of c-Jun.
  • Inhibits sorbitol-induced phosphorylation of c-Jun in HK-2 human tubular epithelial cells.
  • Slows progression of proteinuria and prevents renal impairment in animal models.

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