Apexbio Technology LLC CC-930 899805-25-5 10mg

Supplier:  Apexbio Technology LLC A328810

CC-930 (CAS 899805-25-5) is an orally active selective inhibitor of the c-Jun N-terminal kinase (JNK) family targeting JNK1 JNK2 and JNK3 with IC50 values of 61 nM 7 nM and 6 nM respectively It acts as an ATP-competitive inhibitor as demonstrated by Ki values of 44 3 nM (JNK1) and 6 2 0 6 nM (JNK3) in c-Jun phosphorylation assays CC-930 shows high selectivity for JNK isoforms over other kinases and non-kinase enzymes In cellular models it attenuates TGF- -induced c-Jun phosphorylation and exhibits dose-dependent anti-fibrotic activity in murine skin fibrosis models CC-930 is utilized in research related to JNK signaling fibrotic disease mechanisms and potential therapeutic modulation of stress-activated kinase pathways

Catalog No. 50-000-94090