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Apexbio Technology LLC CCG-1423 285986-88-1 200mg
Supplier: Apexbio Technology LLC B4897200
CCG-1423 (CAS 285986-88-1) is a small molecule inhibitor targeting RhoA transcriptional signaling pathways It disrupts the interaction between myocardin-related transcription factor A (MRTF-A) and importin / 1 while not affecting the binding of monomeric G-actin to MRTF-A CCG-1423 exhibits selective nanomolar to low micromolar potency against cells with Rho pathway overexpression leading to inhibition of DNA synthesis cellular proliferation and invasion In highly metastatic melanoma cells with elevated RhoC it enhances caspase-3 activation indicating a role in apoptosis modulation CCG-1423 serves as a valuable tool for investigating Rho GTPase-mediated processes in cancer and related pathologies
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