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Medchemexpress LLC CCT241533 hydrochloride | 1431697-96-9 | 98.55% | 478.94 | 100 MG
SDP

Catalog No. 5000361654
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CCT241533 hydrochloride is a potent and selective CHK2 inhibitor, demonstrating an IC50 of 3 nM and a Ki of 1.16 nM. It effectively inhibits CHK2 activity in human tumor cell lines when responding to DNA damage and significantly potentiates the cytotoxicity of PARP inhibitors.

  • Potent and selective CHK2 inhibitor with IC50 of 3 nM and Ki of 1.16 nM.
  • Inhibits CHK2 activity in human tumor cell lines in response to DNA damage.
  • Significantly potentiates the cytotoxicity of PARP inhibitors.
  • Demonstrates 63-fold selectivity over CHK1 (IC50=190 nM).
  • Exhibits low hERG inhibition (IC50=22 μM).
  • Blocks CHK2 autophosphorylation at S516.
  • Abolishes induction of pS516 CHK2 signal with PARP inhibitor alone.
  • Shows cytotoxicity in HT-29, HeLa, and MCF-7 cells.

Catalog No. 50-003-61654 Supplier Medchemexpress LLC Supplier No. HY14715B100MG
May include imposed supplier surcharges.
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CCT241533 hydrochloride is a potent and selective CHK2 inhibitor, demonstrating an IC50 of 3 nM and a Ki of 1.16 nM. It effectively inhibits CHK2 activity in human tumor cell lines when responding to DNA damage and significantly potentiates the cytotoxicity of PARP inhibitors.

  • Potent and selective CHK2 inhibitor with IC50 of 3 nM and Ki of 1.16 nM.
  • Inhibits CHK2 activity in human tumor cell lines in response to DNA damage.
  • Significantly potentiates the cytotoxicity of PARP inhibitors.
  • Demonstrates 63-fold selectivity over CHK1 (IC50=190 nM).
  • Exhibits low hERG inhibition (IC50=22 μM).
  • Blocks CHK2 autophosphorylation at S516.
  • Abolishes induction of pS516 CHK2 signal with PARP inhibitor alone.
  • Shows cytotoxicity in HT-29, HeLa, and MCF-7 cells.

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