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Medchemexpress LLC CCZ01048 TFA | 98.5% | 1622.75 | 1 MG
Supplier: Medchemexpress LLC HYP2336A1MG
CCZ01048 TFA is an α-MSH analogue that demonstrates high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. It rapidly internalizes into B16F10 melanoma cells and exhibits high in vivo stability, making it a promising candidate for PET imaging of malignant melanoma. The cationic Pip linker used in CCZ01048 improves tumor uptake and generates high tumor-to-normal tissue contrast in PET imaging within a preclinical melanoma model.
- Exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM
- Rapid internalization into B16F10 melanoma cells
- Shows high in vivo stability
- Promising candidate for PET imaging of malignant melanoma
- Cationic Pip linker improves tumor uptake
- Generates high tumor-to-normal tissue contrast with PET imaging in a preclinical melanoma model
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