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AdipoGen CD112R ms pAb IN109
Supplier: AdipoGen AG25B0035C100
Polyclonal Antibody. Recognizes mouse CD112R. Does not cross-react with human CD112R. Source Rabbit. Application ELISA, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. CD112 also called Nectin-2 or poliovirus receptor-related 2 protein is a type I transmembrane glycoprotein and a member of the Ig gene superfamily IGSF. CD112/Nectin-2 functions as an adhesion molecule involved in the formation of cell junctions and interactions with other Nectin-family molecules. Nectin-2 is a also a surface marker of some endothelial cells and regulates migration, proliferation and angiogenesis. CD112 functions as an immune checkpoint regulator by modulating T cell signaling, either as a costimulator of T cell function, or as a coinhibitor of T cells proliferation by binding to the receptors CD226 or TIGIT T cell Ig and immunoreceptor tyrosine-based inhibitory motif ITIM domain, respectively. The binding of CD112 ligand to these receptors is weak compared to CD155.
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