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Genscript Corporation CD27 Ligand/CD70 Fc Chimera H
Supplier: Genscript Corporation Z03450100
CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene CD70 is a ligand for CD27 The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity in particular during antiviral responses Upon CD27 binding induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells The CD70 protein is expressed on highly activated lymphocytes (like in T- and B-cell lymphomas) It is therefore suggested that anti-CD70 antibodies might be a possible treatment for CD70 positive lymphomas as normal lymphocytes have low CD70 expression
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