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AdipoGen CD276 [B7-H3] (mouse):Fc (mouse) (rec.) (non-lytic) (100 µg)
SDP

Supplier:  AdipoGen CHIMF120B7H3C100

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Recombinant Protein. The extracellular domain of mouse CD276 [B7-H3] (aa 30-248) is fused to the N-terminus of the Fc region of mutant mouse IgG2a. Source/Host: HEK 293 cells. Endotoxin: <0.001EU/µg protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in PBS. CD276 (B7-H3) is a member of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T cell response. B7-H3 provides a stimulatory signal to T cells. However, recent studies suggest a negative regulatory role for B7-H3 in T cell responses. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor or allogeneic antigen-presenting cells. B7-H3 is a negative regulator that preferentially affects T(H)1 responses. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes.

Catalog No. 50-205-4697


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