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AdipoGen CD30 h mAb rec SH313-B5
Supplier: AdipoGen AG27B6314C050
Recombinant Antibody. Recognizes human CD30. Applications ELISA, FACS, FUNC, ICC, WB. Clone SH313-B5. Isotype Human IgG1. Formulation Liquid. In PBS. CD30 Ki-1 TNF Receptor Superfamily Member 8 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L CD153. The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkins disease and other CD30 lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkins and Reed-Sternberg cells, CD30 is also found in some non-Hodgkins lymphomas including Burkitts lymphomas, virus-infected T and B cells, and on normal T and B cells after activation.
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