Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC CD40L/CD154/TRAP Trimer Protein, Human (HEK293, His-Flag) | ≥ 95% | Predicted: 52.4 kDa, Apparent: ~55 kDa | 20 UG
Supplier: Medchemexpress LLC HYP7842520UG
CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5 that generates a costimulatory signal up-regulating IL-4 synthesis. It is specifically expressed on activated CD4+ T-lymphocytes and involved in NF-κB/MAPK pathway activation, B cell differentiation, maturation, and apoptosis. This full-length monomer (M113-L261) is expressed in HEK293 cells with N-terminal His- and Flag-tag, belonging to the tumor necrosis factor (TNF) family. It plays a major role in immune response and is a target for inflammation, binding and signaling through integrins.
- Ligand to CD40/TNFRSF5, generating costimulatory signals
- Expressed on activated CD4+ T-lymphocytes
- Involved in NF-κB/MAPK pathway activation and B cell processes
- Enhances cytokine production like IL-4, IL-10, interferon-γ, and TNF-α
- Induces endothelial cell VCAM-1 expression in vitro and in vivo
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?