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AdipoGen CD40L h multimeric CSG
Supplier: AdipoGen AG40B0010CSGC100
Recombinant protein. Human CD40L aa 116-261 is fused at the N-terminus to mouse ACRP30headless aa 18-111 and a FLAG -tag. Induces B cells activation as demonstrated by dose-dependent upregulation of CD86 ED50 <1ng/ml. B cell expansion online protocol available. Source CHO cells. Produced using certified serum/medium.*. Liquid. Contains PBS. MultimericCD40L™ is a high-activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40Lenhancer combinations. MultimericCD40L™ has been shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time-dependent manner, without affecting BMDM viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators.
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