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Biotium CD61 / Integrin beta-3 / Platelet Glycoprotein IIIa (Platelet Marker) (Y2/51), CF640R conjugate, 0.1mg/mL
Supplier: Biotium BNC401652500
This antibody reacts with human integrin beta-3 (GPIIIa, vitronectin receptor beta chain). It associates with the alphaalpha-V-chain (CD51) to form vitronectin receptor, or with the alphaalpha-IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluo
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