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Medchemexpress LLC Cdc42-IN-1 | 1222513-26-9 | 99.8% | 486.38 | 50 MG
Supplier: Medchemexpress LLC HY13637950MG
CID44216842 (Cdc42-IN-1) is a potent and selective guanine nucleotide binding lead inhibitor targeting Cdc42. It functions as a molecular probe, specifically inhibiting GTP binding to both Cdc42 and its mutant in a dose-dependent manner. This inhibition is specific toward Cdc42 with no effects on other GTPases including Rac and Rho in the same family.
- Potent Cdc42-selective guanine nucleotide binding lead inhibitor
- EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay
- EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay
- Used as a molecular probe
- Specific inhibition of Cdc42 without affecting other GTPases like Rac and Rho
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