Cayman Chemical CDDO methyl ester 50mg

Supplier:  Cayman Chemical 1188350 MG

An EGFR degrader; binds to EGFR (Kd = 5.64 µM) and induces EGFR ubiquitination and degradation in BT-549 breast cancer cells but not in the presence of shRNA targeting the mRNA encoding Keap1; increases the number of autophagosomes in BT-549 cells; inhibits Ifn-γ-induced increases in levels of NO in isolated mouse macrophages (IC50 = 0.11 nM); inhibits TNF-α-induced NF-κB nuclear translocation in KBM5 cells at 1 µM; decreases the viability of SGC-7901, NCI N87, BGC-823, and GES-1 cells (IC50s = 0.6, 0.8, 0.5, and 0.5 µM, respectively); reduces plasma levels of triglycerides, free fatty acids, insulin, blood levels of glucose, liver and muscle levels of total lipids, and muscle levels of triglycerides in mice fed a Western diet at 3 mg/kg per day; decreases tumor volume and weight and the percentage of EGFR+ tumor cells alone or in combination with gefitinib in an HCC1806 breast cancer mouse xenograft model at 2 mg/kg every other day

Catalog No. 50-295-5761