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Medchemexpress LLC CDK12-IN-2 | 2244987-03-7 | 99.4% | 532.64 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY11262610MG

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CDK12-IN-2 is a potent, selective, and nanomolar CDK12 inhibitor with good physicochemical properties. It also acts as a strong CDK13 inhibitor because CDK13 is the closest homologue of CDK12. It demonstrates excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. This compound inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II and can be used as an excellent chemical probe for functional studies of CDK12.

  • Potent, selective, and nanomolar CDK12 inhibitor
  • Strong CDK13 inhibitor
  • Excellent kinase selectivity over CDK2, 9, 8, and 7
  • Inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II
  • Can be used as an excellent chemical probe for functional studies of CDK12

Catalog No. 50-004-36395


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