Invitrogen™ Human CDKL5, GST Tag Recombinant Protein

Catalog No.	Quantity
A30493	10 μg
A32864	100 μg
A33353	1 mg

Catalog No. A30493 Supplier Invitrogen™ Supplier No. A30493

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This CDKL5 recombinant human protein (1-498) was expressed in insect cells. CDKL5 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service. Validated for use with the Z'-LYTE™ assay Available in multiple pack sizes for convenient use Also available in our SelectScreen Kinase Profiling Service Protein Form: Recombinant, Active, Catalytic.

CDKL5 serine/threonine kinase (STK9) is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome and Rett syndrome (RTT). CDKL5 can control nuclear speckle morphology by regulating the phosphorylation state of splicing regulatory proteins, and may be involved indirectly in pre-mRNA processing by controlling splicing factor dynamics. The mutations in CDKL5 are major cause of infantile spasms and early epileptic seizures in female patients, and of a later intractable seizure disorder.

Specifications

• Accession Number: O76039
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris HCl with 0.25mM DTT, 25% glycerol, 0.1mM PMSF, 0.1mM EDTA, 150mM NaCl, 10mM glutathione and no preservative; pH 7.5
• Gene ID (Entrez): 6792
• Molecular Weight (g/mol): 82.7 kDa
• Name: Human CDKL5, GST Tag
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 10 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: BC038161; Cdkl5; CFAP247; cyclin dependent kinase 5 transcript; cyclin dependent kinase like 5; cyclin-dependent kinase-like 5; EIEE2; ISSX; RP1-245G19.3; serine/threonine kinase 9; serine/threonine-protein kinase 9; STK9
• Common Name: CDKL5
• Gene Symbol: CDKL5
• Kinase Family: CDKs and CHKs
• Protein Length: 1-498
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Sequence: 1-498
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Shipping Condition: Dry Ice
• Expression System: Insect cells
• Protein Family: Kinases & Inhibitors
• Protein Form: Recombinant, Active, Catalytic
• Form: Liquid