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ABclonal Technology CDKN1A/p21 Rabbit
SDP

Catalog No. 5000006876
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This gene encodes a cyclin-dependent kinase inhibitor that regulates cell cycle progression at the G1 phase by binding and inhibiting cyclin-CDK2 and cyclin-CDK4 complexes Its expression is controlled by the tumor suppressor p53 enabling p53-dependent G1 arrest in response to stress The protein also interacts with proliferating cell nuclear antigen (PCNA) influencing DNA replication and repair It can be cleaved by caspase-3-like enzymes leading to CDK2 activation and promoting apoptosis Mice lacking this gene show enhanced tissue regeneration Multiple splice variants exist

Catalog No. 50-000-06876 Supplier ABclonal Technology Supplier No. A22460PM100UL
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This gene encodes a cyclin-dependent kinase inhibitor that regulates cell cycle progression at the G1 phase by binding and inhibiting cyclin-CDK2 and cyclin-CDK4 complexes Its expression is controlled by the tumor suppressor p53 enabling p53-dependent G1 arrest in response to stress The protein also interacts with proliferating cell nuclear antigen (PCNA) influencing DNA replication and repair It can be cleaved by caspase-3-like enzymes leading to CDK2 activation and promoting apoptosis Mice lacking this gene show enhanced tissue regeneration Multiple splice variants exist

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