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Medchemexpress LLC CE3F4 | 143703-25-7 | 98.9% | 351.01 | 1 ML
Supplier: Medchemexpress LLC HY108539100MG
CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1), with higher activity against Epac1 than Epac2(B). It effectively reduces the exchange activity of Epac1. This compound offers a targeted approach for studying Epac1-mediated pathways.
- Selective antagonist of Epac1.
- Inhibits Epac1 guanine nucleotide exchange activity.
- Does not interfere with Rap1 activity or Epac1-Rap1 interaction.
- No influence on PKA activity.
- Inhibits Epac-induced Rap1 activation in cultured HEK293 cells.
- Significantly inhibits the late phase of ERK activation stimulated by glucose in INS-1 cells.
- Inhibits atrial fibrillation and ventricular arrhythmias in animal models.
- Improves cardiac function after myocardial infarction in mice.
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