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Apexbio Technology LLC Cediranib (AZD217) 288383-20-0 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A18825.1

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Cediranib (AZD2171 CAS 288383-20-0) is an orally bioavailable small molecule inhibitor targeting the kinase insert domain receptor (KDR VEGFR-2) with potent inhibition observed in recombinant assays (IC50 1 nM) Additionally cediranib suppresses related vascular endothelial growth factor receptors VEGFR-1 (Flt-1 IC50 5 nM) and VEGFR-3 (Flt-4 IC50 3 nM) It also blocks select platelet-derived growth factor receptors notably c-Kit PDGFR PDGFR and CSF-1R at nanomolar to sub-micromolar concentrations indicating multiple-kinase targeting capability Cediranib serves as a valuable research compound for studying tumor angiogenesis and kinase-driven oncogenic pathways

Catalog No. 50-000-63097


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