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Apexbio Technology LLC Cefoperazone 62893-19-0 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A83925.1
Cefoperazone is a third-generation cephalosporin antibiotic with broad-spectrum antibacterial activity widely applied in biomedical research focused on transport-related mechanisms It exhibits inhibitory effects on rMrp2-mediated transport of [ 3H]estradiol-17 -glucuronide ([ 3H]E217 G) with a reported IC50 value of approximately 199 M Importantly the inhibitory profile of cefoperazone displays biphasic characteristics suggesting distinct binding sites the obtained IC50 values are 6 66 3 23 M (high-affinity component) and 3 88 1 32 mM (low-affinity component) These properties facilitate its use as a probe compound to assess transport pathways in pharmacokinetic and drug disposition studies
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