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Medchemexpress LLC Ceftolozane sulfate | 936111-69-2 | 99.7% | 764.77 | 1 MG
Supplier: Medchemexpress LLC HY19806A1MG
Ceftolozane sulfate is an antipseudomonal cephalosporin that binds to *P. aeruginosa* essential PBPs (1b, 1c, 2 and 3) with high affinity, inhibiting cell wall synthesis. It is effective against *P. aeruginosa* and Enterobacteriaceae.
- Inhibits *P. aeruginosa* PAO1 with an MIC of 0.5 μg/mL
- Effective against AmpC-derepressed *P. aeruginosa*
- Exhibits antipseudomonal activity against carbapenem-resistant and multi-drug resistant isolates
- Reduces ESBL-producing Enterobacteriaceae in vivo
- Reduces bacterial load and improves pulmonary inflammatory response in *P. aeruginosa* pneumonia models
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